Fliposomes: trans-2-aminocyclohexanol-based amphiphiles as pH-sensitive conformational switches of liposome membrane – a structure-activity relationship study
نویسندگان
چکیده
منابع مشابه
trans-2-Aminocyclohexanol as a pH-sensitive conformational switch in lipid amphiphiles.
Protonation-induced conformational change of lipid tails is reported as a novel strategy to render pH-sensitive lipid amphiphiles and lipid colloids.
متن کاملtrans-2-Aminocyclohexanol as a pH-sensitive conformational switch in lipid amphiphileswz
Conformationally controlled molecular switches are central devices of molecular machines and provide a new and promising approach to materials with controllable properties. However, the concept of conformational switches has not yet been applied to the design of triggerable lipid amphiphiles. The potential advantage here is that the effect of the conformational switch in one molecule of lipid a...
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Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic conformational flip upon protonation that disrupts the liposome membrane and causes rapid release of cargo specifically in areas of increased acidity. pH-sensitive liposomes containing the amphiphile (1) with trans-2-morpholinocyclohexanol conformational switch, a phospholipid, and a PEG-lipid conjuga...
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Sonicated unilamellar liposomes containing phosphatidylethanolamine and palmitoylhomocysteine fuse rapidly when the medium pH is lowered from 7 to 5. Liposome fusion was demonstrated by (i) mixing of the liposomal lipids as shown by resonance energy transfer, (ii) gel filtration, and (iii) electron microscopy. The pH-sensitive fusion of liposomes was observed only when palmitoylhomocysteine (gr...
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Among various phenolic compounds, caffeic acid (3,4-dihydroxycinnamic acid) exhibited pharmacological antioxidant, anticancer and antimutagenic activities. The antioxidant properties of phenolic compounds depend on their chemical structure, however, the role of the ethylenic side chain in the radical scavenging activity remains controversial. Thus, the aim of this study consisted to test cinnam...
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ژورنال
عنوان ژورنال: Chemistry and Physics of Lipids
سال: 2018
ISSN: 0009-3084
DOI: 10.1016/j.chemphyslip.2017.10.004